Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ)

J Med Chem. 2000 Oct 19;43(21):3820-3. doi: 10.1021/jm000065c.
No abstract available

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Animals
  • Anti-Asthmatic Agents / chemical synthesis*
  • Anti-Asthmatic Agents / chemistry
  • Anti-Asthmatic Agents / pharmacology
  • Azides / chemical synthesis*
  • Azides / chemistry
  • Azides / pharmacology
  • Bronchoconstriction / drug effects
  • Cell Line
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Ferrets
  • Guinea Pigs
  • Humans
  • Photoaffinity Labels / chemical synthesis
  • Photoaffinity Labels / chemistry
  • Photoaffinity Labels / pharmacology
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry
  • Quinolines / pharmacology
  • Recombinant Fusion Proteins / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Vomiting / chemically induced*

Substances

  • 8-(3-azidophenyl)-6-((4-iodo-1H-1-imidazolyl)methyl)quinoline
  • Anti-Asthmatic Agents
  • Azides
  • Enzyme Inhibitors
  • Photoaffinity Labels
  • Quinolines
  • Recombinant Fusion Proteins
  • Tumor Necrosis Factor-alpha
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4